1. Combine the Honey, Italian seasoning, and soy sauce in a Ziploc bag and shake well. Then, add the London broil and shake again, so it mixes on the meat. Toss in the fridge to marinate for two to eight hours.
2. Set the oven to 375F and let it preheat. Then, take the London broil out and place it in a baking container. Broil on the lowest rack for five to six minutes, then flip and cook again for another three to four minutes.
3. Set the meat down when the internal temperature reaches 125 for medium-rare or 145 for well-done. Then, rest the beef for five to ten minutes and serve sliced against the grain.

If you want more ideas on cooking London broil in a 375F oven, click on this video recipe.