1. Set your oven to 400 degrees Fahrenheit and leave it to preheat. Aluminum foil or parchment paper should be used to line a baking sheet in the meantime. In a food processor, pulse the bread until fine crumbs are formed from them. Transfer the breadcrumbs into a small mixing dish and add the milk. Allow for a 10-minute rest period, stirring the mixture occasionally.
2. In another large mixing bowl, combine the beef, onion, pork, egg, garlic, ¼ cup of ketchup, 1¼ teaspoons of pepper, and ½ teaspoon of salt. Pour the bread-milk combination into the mixture and stir it gradually using a fork (make sure not to overmix).
3. Form the meat mixture into a loaf approximately 9 inches in length and 4 to 5 inches in width; do this on the prepared baking sheet.
4. Bake the meatloaf for 45 to 55 minutes, brushing twice with the remaining ¼ cup of ketchup during the baking process. Leave the meatloaf in the oven until it registers 160 degrees when checked with an instant-read thermometer.
5. Take the meatloaf out of the oven afterward, and allow it to stand for a 10-minute resting period before slicing and serving.

This meatloaf recipe is easy to follow, and you’ll find that it offers really satisfying results. The entire cooking duration lasts for 1 hour and 30 minutes, with a bake time of 55 minutes. For more recipe ideas for cooking meatloaf at 400 degrees, we recommend that you watch this video recipe.