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Shrimp Penne Casserole Recipe

Shrimp penne casserole is a very simple and delicious seafood dish. This recipe consists of ingredients such as shrimp, mozzarella cheese, parmesan cheese, garlic and spinach; with a combination like this you cannot go wrong. If you are looking for a quick dinner this is an excellent choice because this casserole only takes about 40 minutes to prepare including the cooking time. If you don’t want to use shrimp, a good alternative would be to use sliced cooked chicken breasts. A good alternative to mozzarella cheese would be Italian cheese blend. This goes great served with garlic bread. Enjoy.

Cooking Instructions:

(Makes 6 Servings)

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Shrimp Penne Casserole Recipe

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  • Total Time: 30 minutes


  • 3 cups uncooked penne pasta
  • 2 eggs
  • ½ cup half-and-half cream
  • 4 tablespoons butter (melted)
  • 1 cup grated parmesan cheese
  • 2 cups shredded mozzarella cheese
  • 2 garlic cloves (minced)
  • ½ teaspoon salt
  • ¼ teaspoon ground black pepper
  • 1lb uncooked medium shrimp, peeled and deveined with tails removed
  • 1 ½ cups fresh spinach (chopped)


  1.  Pre-heat the oven to 350 degrees. Cook penne pasta according to package directions. In a small bowl combine eggs, half-and-half, and butter; set aside. Drain the pasta and place it into a large bowl. Add parmesan cheese, 1 cup mozzarella cheese, garlic, salt, pepper, and reserved egg mixture; toss to coat. Stir in shrimp and spinach.
  2.  Lightly grease a 9×13 inch baking dish. Pour the shrimp and penne mixture into the baking dish and top with leftover mozzarella cheese.
  3.  Place into the oven and bake uncovered at 350 degrees for 20-25 minutes or until the shrimp turn pink and the cheese has melted.
  • Author: Bobby
Recipe rating 5 Stars 4 Stars 3 Stars 2 Stars 1 Star

Loretta B

Thursday 11th of April 2024

Do you defrost shrimp before cooking?

Catherine Brock

Saturday 13th of April 2024

Loretta, Yes, if you are using frozen shrimp, thaw before cooking. You can add uncooked, thawed shrimp to the casserole and it cooks in the oven. ~Catherine


Saturday 8th of March 2014

I prefer broccoli to spinach. Do you think that would work? Recipe sounds fantastic. Anxious to try it!


Sunday 9th of March 2014

Yes, broccoli would work in place to spinach. Enjoy the recipe.


Thursday 27th of February 2014

This dish is exceptionally delicious! I prepared it exactly as it was written, and it couldn't have been any better than it was. It's pretty high in fat & carbs, so I'll only make it 'occasionally' - but we'll be looking forward to enjoying it again & again. I've already signed up to receive your blog.


Wednesday 19th of February 2014

This looks so tasty! Thanks!


Tuesday 18th of February 2014

To print just the recipe: 1) highlight and "copy" the whole recipe including pictures 2) open Word and paste. 3) if you want to edit out the pictures, just highlight and "cut". 4) if you want to edit any text just highlight and "delete" 5) recipe will be on 1 page